Guinea Pig Clarin-1 (CLRN1) ELISA Kit | CLRN1 elisa kit
Guinea pig Clarin-1 (CLRN1) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
USH3A: May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. Defects in CLRN1 are the cause of Usher syndrome type 3A (USH3A). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual progressive deafness and onset of retinitis pigmentosa in the second decade of life. Defects in CLRN1 are the cause of retinitis pigmentosa type 61 (RP61). RP61 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the clarin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q25
Cellular Component: microvillus; lamellipodium; plasma membrane; integral to membrane
Biological Process: sensory perception of sound; visual perception; sensory perception of light stimulus; photoreceptor cell maintenance; response to stimulus; cell motility involved in cell locomotion; actin filament organization; auditory receptor cell stereocilium organization and biogenesis; equilibrioception
Disease: Retinitis Pigmentosa; Usher Syndrome, Type Iiia; Retinitis Pigmentosa 61
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Product Notes
The Guinea Pig CLRN1 clrn1 (Catalog #AAA7208659) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7208659 ELISA Kit recognizes Guinea Pig CLRN1. It is sometimes possible for the material contained within the vial of "Clarin-1 (CLRN1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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