Guinea Pig Charged multivesicular body protein 4a (CHMP4A) ELISA Kit | CHMP4A elisa kit
Guinea pig Charged multivesicular body protein 4a (CHMP4A) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Uniprot Description
CHMP4A: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. Belongs to the SNF7 family.
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: internal side of plasma membrane; cytoplasmic vesicle membrane; membrane coat; late endosome membrane; cytoplasm; plasma membrane; midbody; cytosol; nucleus; endosome
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; lipid binding; ATPase binding
Biological Process: protein polymerization; viral reproduction; cell separation during cytokinesis; vacuolar transport; membrane invagination; viral infectious cycle; posttranslational protein targeting to membrane; endosome transport; mitotic metaphase plate congression; protein homooligomerization; nuclear organization and biogenesis; membrane budding
Research Articles on CHMP4A
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Product Notes
The Guinea Pig CHMP4A chmp4a (Catalog #AAA7220185) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7220185 ELISA Kit recognizes Guinea Pig CHMP4A. It is sometimes possible for the material contained within the vial of "Charged multivesicular body protein 4a (CHMP4A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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