Guinea Pig CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) ELISA Kit | CDK5RAP2 elisa kit
Guinea pig CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
neuronal cyclin-dependent kinase 5 (Cdk5) activator binding protein [RGD, Feb 2006]
Uniprot Description
CDK5RAP2: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Defects in CDK5RAP2 are the cause of microcephaly primary type 3 (MCPH3). A disorder defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Cellular Component: Golgi apparatus; spindle pole; centrosome; microtubule; pericentriolar material; cell; perinuclear region of cytoplasm; cytoplasm; cell junction
Molecular Function: tubulin binding; calmodulin binding; microtubule binding; protein complex binding; protein kinase binding
Biological Process: negative regulation of neuron differentiation; establishment of mitotic spindle orientation; neurogenesis; regulation of neuron differentiation; centrosome organization and biogenesis; positive regulation of transcription, DNA-dependent; microtubule cytoskeleton organization and biogenesis; brain development; negative regulation of centriole replication; microtubule bundle formation; chromosome segregation
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Product Notes
The Guinea Pig CDK5RAP2 cdk5rap2 (Catalog #AAA7243902) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7243902 ELISA Kit recognizes Guinea Pig CDK5RAP2. It is sometimes possible for the material contained within the vial of "CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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