Guinea Pig Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3) ELISA Kit | NDST3 elisa kit
Guinea pig Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Uniprot Description
NDST3: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.8.2.8; Transferase; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity
Biological Process: heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process
Research Articles on NDST3
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Product Notes
The Guinea Pig NDST3 ndst3 (Catalog #AAA7204443) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7204443 ELISA Kit recognizes Guinea Pig NDST3. It is sometimes possible for the material contained within the vial of "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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