Guinea Pig AP-4 complex subunit epsilon-1 (AP4E1) ELISA Kit | AP4E1 elisa kit
Guinea pig AP-4 complex subunit epsilon-1 (AP4E1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
AP4E1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4E1 are the cause of cerebral palsy spastic quadriplegic type 4 (CPSQ4). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication. Belongs to the adaptor complexes large subunit family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: Golgi apparatus; membrane coat; coated pit
Biological Process: vesicle-mediated transport; intracellular protein transport
Disease: Spastic Paraplegia 51, Autosomal Recessive
Research Articles on AP4E1
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Product Notes
The Guinea Pig AP4E1 ap4e1 (Catalog #AAA7248609) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7248609 ELISA Kit recognizes Guinea Pig AP4E1. It is sometimes possible for the material contained within the vial of "AP-4 complex subunit epsilon-1 (AP4E1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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