Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: Hela10% SDS PAGE diluted at 1:1000)
Rabbit anti-Human COX15 Polyclonal Antibody | anti-COX15 antibody
COX15 Antibody
Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: Hela10% SDS PAGE diluted at 1:1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: Hela10% SDS PAGE diluted at 1:1000)
NCBI and Uniprot Product Information
NCBI Description
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]
Uniprot Description
COX15: May be involved in the biosynthesis of heme A. Defects in COX15 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Defects in COX15 are a cause of Leigh syndrome (LS). An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Belongs to the COX15/CtaA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Energy Metabolism - oxidative phosphorylation; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chain
Molecular Function: cytochrome-c oxidase activity; oxidoreductase activity, acting on the CH-CH group of donors
Biological Process: respiratory chain complex IV assembly; porphyrin metabolic process; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; respiratory gaseous exchange; heme a biosynthetic process; heme biosynthetic process
Disease: Leigh Syndrome; Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 2
Research Articles on COX15
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Product Notes
The COX15 cox15 (Catalog #AAA9406912) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COX15 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's COX15 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500-1:3000. Researchers should empirically determine the suitability of the COX15 cox15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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