Metabotropic Glutamate Receptor 2 Assay System | GRM2 assay system

Metabotropic Glutamate Receptor 2 (GRM2) ACTOne Stable Cell Line

• Gene Names: GRM2; GLUR2; mGlu2; GPRC1B; MGLUR2
• Synonyms: Metabotropic Glutamate Receptor 2; Metabotropic Glutamate Receptor 2 (GRM2) ACTOne Stable Cell Line; Metabotropic Glutamate Receptor 2 (GRM2) ACTOneTM Stable Cell Line; GRM2 assay system

• Sequence Length: 872

• Application Notes: cAMP dependent human GRM2 cell-based assay; cell-based high-throughput screening of human GRM2 inhibitors
• Preparation and Storage: Product is shipped on dry ice. Storage: Remove the frozen cells from the dry ice packaging and immediately place the cells at a temperature below -130 degrees C preferably in liquid nitrogen vapor, until ready for use.

Related Product Information for GRM2 assay system

Background/Introduction: The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Product Categories/Family for GRM2 assay system

Cell Based GPCR-PDE Compound Assay System; ACTOne Assay on G-Protein Coupled Receptors (GPCRs)

NCBI and Uniprot Product Information

• NCBI GI #: 66529100
• NCBI GeneID: 2912
• NCBI Accession #: NP_000830.2
• NCBI GenBank Nucleotide #: NM_000839.3
• Molecular Weight: 95,568 Da
• NCBI Official Full Name: metabotropic glutamate receptor 2 isoform a
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 2
• NCBI Official Symbol: GRM2
• NCBI Official Synonym Symbols: GLUR2; mGlu2; GPRC1B; MGLUR2
• NCBI Protein Information: metabotropic glutamate receptor 2; glutamate metabotropic receptor 2; glutamate receptor homolog
• UniProt Protein Name: Metabotropic glutamate receptor 2
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM2
• UniProt Entry Name: GRM2_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

mGluR2: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 3; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: presynaptic membrane; integral to plasma membrane; axon; dendrite; plasma membrane; intracellular; cell junction

Molecular Function: G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity; glutamate receptor activity

Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; glutamate secretion; negative regulation of adenylate cyclase activity; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway