mGluR1, Rat Recombinant Protein | Grm1 recombinant protein
mGluR1, Recombinant, Rat (Metabotropic Glutamate Receptor)
Purified
Purified
NCBI and Uniprot Product Information
NCBI Description
may play a role in synaptic transmission; may modulate perception of pain in arthritis [RGD, Feb 2006]
Uniprot Description
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Ref.1 Ref.2 Ref.4
Subunit structure: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3
By similarity. Interacts with SIAH1 and GRASP. Ref.5 Ref.6 Ref.7 Ref.8
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb. Ref.1 Ref.2
Miscellaneous: Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate; inhibited by 2-amino-3-phosphonopropionate.
Sequence similarities: Belongs to the G-protein coupled receptor 3 family.
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Product Notes
The Grm1 grm1 (Catalog #AAA637732) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's mGluR1, Rat can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable as an inhibitory agent or as an immunoblotting positive control., Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the Grm1 grm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "mGluR1, Rat, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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