Glutamate [NMDA] receptor subunit epsilon-2 (Grin2b) Recombinant Protein | Grin2b recombinant protein
Recombinant Mouse Glutamate [NMDA] receptor subunit epsilon-2 (Grin2b) , partial
NCBI and Uniprot Product Information
Uniprot Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:1377365, PubMed:26912815). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). Contributes to neural pattern formation in the developing brain (PubMed:8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948).
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Product Notes
The Grin2b grin2b (Catalog #AAA963772) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-557. Partial. The amino acid sequence is listed below: RSQKSAPSIG IAVILVGTSD EVAIKDAHEK DDFHHLSVVP RVELVAMNET DPKSIITRIC DLMSDRKIQG VVLADDTDQE AIAQILDFIS AQTLTPILGI HGGSSMIMAD KDESSMFFQF GPSIEQQASV MLNIMEEYDW YIFSIVTTYF PGYQDFVNKI RSTIENSFVG WELEEVLLLD MSLDDGDSKI QNQLKKLQSP IILLYCTKEE ATYIFEVANS VGLTGYGYTW IVPSLVAGDT DTVPSEFPTG LISVSYDEWD YGLPARVRDG IAIITTAASD MLSEHSFIPE PKSSCYNTHE KRIYQSNMLN RYLINVTFEG RNLSFSEDGY QMHPKLVIIL LNKERKWERV GKWKDKSLQM KYYVWPRMCP ETEEQEDDHL SIVTLEEAPF VIVESVDPLS GTCMRNTVPC QKRIISENKT DEEPGYIKKC CKGFCIDILK KISKSVKFTY DLYLVTNGKH GKKINGTWNG MIGEVVMKRA YMAVGSLTIN EERSEVVDFS VPFIETGISV MVSRSNGTVS PSAFLEPFSA D . It is sometimes possible for the material contained within the vial of "Glutamate [NMDA] receptor subunit epsilon-2 (Grin2b), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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