Goat Cytidine deaminase (CDA) ELISA Kit | CDA elisa kit
Goat Cytidine deaminase (CDA) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Uniprot Description
CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.
Protein type: Hydrolase; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.4.5
Chromosomal Location of Human Ortholog: 1p36.2-p35
Cellular Component: extracellular region; cytosol
Molecular Function: protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity
Biological Process: cell surface receptor linked signal transduction; cytosine metabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; cytidine deamination; pyrimidine nucleoside salvage; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization