Goat B-cell lymphoma/leukemia 11A (BCL11A) ELISA Kit | BCL11A elisa kit

Goat B-cell lymphoma/leukemia 11A (BCL11A) ELISA Kit

Gene Names

BCL11A; EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL

Reactivity

Goat

Synonyms

B-cell lymphoma/leukemia 11A (BCL11A); Goat B-cell lymphoma/leukemia 11A (BCL11A) ELISA Kit; BCL11A elisa kit

Ordering
Cat. Num. AAA7234119 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Goat

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Preparation and Storage

Store all reagents at 2-8 degree C.

Product Categories/Family for BCL11A elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

NCBI GI #

20336305

NCBI GeneID

53335

NCBI Accession #

NP_075044.2

NCBI GenBank Nucleotide #

NM_022893.3

Molecular Weight

87,554 Da

NCBI Official Full Name

B-cell lymphoma/leukemia 11A isoform 1

NCBI Official Synonym Full Names

B-cell CLL/lymphoma 11A (zinc finger protein)

NCBI Official Symbol

BCL11A

NCBI Official Synonym Symbols

EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL

NCBI Protein Information

B-cell lymphoma/leukemia 11A; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1

UniProt Protein Name

B-cell lymphoma/leukemia 11A

Protein Family

B-cell lymphoma/leukemia

UniProt Gene Name

BCL11A

UniProt Synonym Gene Names

CTIP1; EVI9; KIAA1809; ZNF856; BCL-11A; EVI-9

UniProt Entry Name

BC11A_HUMAN

NCBI Description

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein homodimerization activity; protein heterodimerization activity; metal ion binding; transcription corepressor activity

Biological Process: protein sumoylation; transcription, DNA-dependent; B cell differentiation; regulation of dendrite development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of collateral sprouting; negative regulation of axon extension; positive regulation of collateral sprouting; T cell differentiation; negative regulation of protein homooligomerization

Research Articles on BCL11A

1. Twelve SNPs at the BCL11A gene were shown to modify HbF levels.

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Product Notes

The Goat BCL11A bcl11a (Catalog #AAA7234119) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7234119 ELISA Kit recognizes Goat BCL11A. It is sometimes possible for the material contained within the vial of "B-cell lymphoma/leukemia 11A (BCL11A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Goat B-cell lymphoma/leukemia 11A (BCL11A) ELISA Kit | BCL11A elisa kit