Goat ATP synthase subunit alpha, mitochondrial (ATP5A1) ELISA Kit | ATP5A1 elisa kit

Goat ATP synthase subunit alpha, mitochondrial (ATP5A1) ELISA Kit

Cat. Num. AAA7246623

• Gene Names: ATP5A1; OMR; ORM; ATPM; MOM2; ATP5A; hATP1; MC5DN4; ATP5AL2; HEL-S-123m
• Reactivity: Goat
• Synonyms: ATP synthase subunit alpha; mitochondrial (ATP5A1); Goat ATP synthase subunit alpha; mitochondrial (ATP5A1) ELISA Kit; ATP5A1 elisa kit

• Reactivity: Goat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for ATP5A1 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 382546007
• NCBI GeneID: 498
• NCBI Accession #: NP_001244263.1
• NCBI GenBank Nucleotide #: NM_001257334.1
• Molecular Weight: 57,547 Da
• NCBI Official Full Name: ATP synthase subunit alpha, mitochondrial isoform b
• NCBI Official Synonym Full Names: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
• NCBI Official Symbol: ATP5A1
• NCBI Official Synonym Symbols: OMR; ORM; ATPM; MOM2; ATP5A; hATP1; MC5DN4; ATP5AL2; HEL-S-123m
• NCBI Protein Information: ATP synthase subunit alpha, mitochondrial; ATP sythase (F1-ATPase) alpha subunit; ATP synthase alpha chain, mitochondrial; epididymis secretory sperm binding protein Li 123m; mitochondrial ATP synthetase, oligomycin-resistant; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2
• UniProt Protein Name: ATP synthase subunit alpha, mitochondrial
• UniProt Gene Name: ATP5A1
• UniProt Synonym Gene Names: ATP5A; ATP5AL2; ATPM
• UniProt Entry Name: ATPA_HUMAN

NCBI Description

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Uniprot Description

ATP5A1: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Belongs to the ATPase alpha/beta chains family.

Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Transporter; EC 3.6.3.14; Mitochondrial

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: signalosome; membrane; mitochondrion; mitochondrial matrix; proton-transporting ATP synthase complex, catalytic core F(1); mitochondrial inner membrane; plasma membrane; mitochondrial proton-transporting ATP synthase complex

Molecular Function: protein binding; MHC class I protein binding; ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding

Biological Process: cellular metabolic process; embryonic development; ATP biosynthetic process; negative regulation of endothelial cell proliferation; ATP hydrolysis coupled proton transport; mitochondrial ATP synthesis coupled proton transport; lipid metabolic process

Disease: Combined Oxidative Phosphorylation Deficiency 22; Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 4