Goat Apolipoprotein CII Antibody | anti-Apo CII antibody

Biotinylated Goat Anti-Human Apolipoprotein CII

Cat. Num. AAA390021

• Gene Names: APOC2; APO-CII; APOC-II
• Applications: ELISA, Immunoblot, Western Blot
• Synonyms: Apolipoprotein CII; Biotinylated Goat Anti-Human Apolipoprotein CII; Biotinylated Sheep Anti-Human Apolipoprotein CII (apoCII); Polyclonal Antibody; anti-Apo CII antibody

• Host: Goat
• Specificity: Specifically binds to human apoCII. Dilution for immunoblot and ELISA range: 200 to 5,000
• Form/Format: 0.5 ml in Freeze dried powder.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 101

• Applicable Applications for anti-Apo CII antibody: ELISA (EIA), Immunoblot (IB)
• Application Notes: Freeze-dried powder. Dilution for Immunoblot & ELISA range: 1,000 to 5,000.; Use: The antibody can be used for detection of apoCII in human plasma and lipoproteins, immunoassays and immunoblots.
• Host Note: Polyclonal goat anti-recombinant human apo CII purified by human apo CII-Sepharose an labeled with biotin.
• Preservation: In 75 mM Sodium Phosphate, 75 mM NaCI, 0.02% NaN ₃, 0.05 mM EDTA, pH 7.2
• Stabilizer: 10 mg/mL bovine serum albumin (BSA).
• Preparation and Storage: Freeze-dried product should be refrigerated until opened. After opening, restore to 0.5 ml with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4 degree C as an undiluted liquid. Do not use for more than one day after dilution.For extended storage after reconstitution we suggest to aliquot to avoid repeated freezing and thawing; or the addition of an equal volume of glycerol to make a final glycerol concentration of 50%, followed by storage at -20°C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol.

Product Categories/Family for anti-Apo CII antibody

Biotin Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 32130518
• NCBI GeneID: 344
• NCBI Accession #: NP_000474.2
• NCBI GenBank Nucleotide #: NM_000483.4
• UniProt Accession #: P02655; Q9BS39; Q9UDE3; Q9UNK3; C0JYY4
• NCBI Official Full Name: apolipoprotein C-II
• NCBI Official Synonym Full Names: apolipoprotein C-II
• NCBI Official Symbol: APOC2
• NCBI Official Synonym Symbols: APO-CII; APOC-II
• NCBI Protein Information: apolipoprotein C-II; apolipoprotein C2
• UniProt Protein Name: Apolipoprotein C-II
• UniProt Gene Name: APOC2
• UniProt Synonym Gene Names: APC2; Apo-CII; ApoC-II
• UniProt Entry Name: APOC2_HUMAN

NCBI Description

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular location: Secreted.

Tissue specificity: Secreted in plasma.

Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities: Belongs to the apolipoprotein C2 family.