Goat Apolipoprotein CI Antibody | anti-Apo CI antibody

Biotinylated Goat Anti-Human Apolipoprotein CI

Cat. Num. AAA390018

• Applications: ELISA, Immunoblot, Western Blot
• Synonyms: Apolipoprotein CI; Biotinylated Goat Anti-Human Apolipoprotein CI; Biotinylated Goat Anti-Human Apolipoprotein CI (Apo CI); Polyclonal Antibody; anti-Apo CI antibody

• Host: Goat
• Specificity: Specifically binds to human apo CI. Dilution for immunoblot and ELISA range: 200 to 8,000.
• Concentration: 1.2 mg / ml in freeze-dried powder (varies by lot)
• Sequence Length: 83

• Applicable Applications for anti-Apo CI antibody: ELISA (EIA), Immunoblot (IB)
• Application Notes: Freeze-dried powder. Dilution for Immunoblot & ELISA range: 1,000 to 8,000.; Use: The antibody can be used for detection of apo CI in human plasma and lipoproteins, immunoassays and immunoblots.
• Source Note: Polyclonal antibody purified by human apo CI-Sepharose affinity column and labeled with biotin.
• Preservative: 75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2.
• Stabilizer: 10 mg / ml Bovine Serum Albumin.
• Preparation and Storage: Freeze-dried product should be refrigerated until opened. After opening, restore to 0.5 ml with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4 degree C as an undiluted liquid. Do not use for more than one day after dilution. For extended storage after reconstitution, we suggest the addition of an equal volume of glycerol to make a final glycerol concentration of 50% followed by storage at -20 degree C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol.

Product Categories/Family for anti-Apo CI antibody

Biotin Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 757914
• NCBI GeneID: 341
• UniProt Accession #: P02654; Q6IB97
• Molecular Weight: 9,332 Da
• NCBI Official Full Name: apolipoprotein CI
• NCBI Official Synonym Full Names: apolipoprotein C-I
• NCBI Official Symbol: APOC1
• NCBI Protein Information: apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1
• UniProt Protein Name: Apolipoprotein C-I
• UniProt Gene Name: APOC1
• UniProt Entry Name: APOC1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Ref.13

Subcellular location: Secreted.

Tissue specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.

Miscellaneous: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).

Sequence similarities: Belongs to the apolipoprotein C1 family.