Goat NOS1AP / CAPON Polyclonal Antibody | anti-NOS1AP antibody

Goat Polyclonal to Human NOS1AP / CAPON

Cat. Num. AAA243202

• Gene Names: NOS1AP; CAPON; 6330408P19Rik
• Reactivity: Gorilla, Hamster, Human, Monkey, Mouse, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: NOS1AP / CAPON; Polyclonal Antibody; Goat Polyclonal to Human NOS1AP / CAPON; Anti-NOS1AP / CAPON Antibody IHC-plus; NOS1AP; KIAA0464; CAPON; Human NOS1AP; anti-NOS1AP antibody

• Host: Goat
• Reactivity: Gorilla, Hamster, Human, Monkey, Mouse, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human NOS1AP. This antibody is expected to recognise both reported isoforms.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 211

• Applicable Applications for anti-NOS1AP antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide PSKTKYNLVDDGH-C from the N-terminus of human NOS1AP (NP_055512.1; NP_001158229.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster (100%); Pufferfish, Zebrafish (92%).
• Immunogen Type: Synthetic peptide
• Immunogen: NOS1AP / CAPON antibody was raised against synthetic peptide PSKTKYNLVDDGH-C from the N-terminus of human NOS1AP (NP_055512.1; NP_001158229.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster (100%); Pufferfish, Zebrafish (92%).
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-NOS1AP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 205277334
• NCBI GeneID: 9722
• NCBI Accession #: NP_001119532.2
• NCBI GenBank Nucleotide #: NM_001126060.1
• UniProt Accession #: O75052; O43564; Q3T551; Q5VU95; B7ZLF5
• Molecular Weight: 55,569 Da
• NCBI Official Full Name: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2
• NCBI Official Synonym Full Names: nitric oxide synthase 1 (neuronal) adaptor protein
• NCBI Official Symbol: NOS1AP
• NCBI Official Synonym Symbols: CAPON; 6330408P19Rik
• NCBI Protein Information: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 adaptor protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain
• UniProt Protein Name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• Protein Family: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• UniProt Gene Name: NOS1AP
• UniProt Synonym Gene Names: CAPON; KIAA0464
• UniProt Entry Name: CAPON_HUMAN

NCBI Description

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

Uniprot Description

NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nuclear membrane; sarcoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; T-tubule; caveola; Z disc; cytosol; nucleus; sarcolemma

Molecular Function: nitric-oxide synthase binding

Biological Process: regulation of apoptosis; regulation of nitric oxide biosynthetic process; positive regulation of nitric oxide biosynthetic process; chemical signal regulation of heart rate; positive regulation of nitric-oxide synthase activity; regulation of nitric-oxide synthase activity

Disease: Qt Interval, Variation In