GnRH I Blocking Peptide | GnRHI blocking peptide

GnRH I (D43) Peptide

Cat. Num. AAA3003157

• Gene Names: GNRH1; GRH; GNRH; LHRH; LNRH
• Applications: Blocking
• Purity: Synthetic peptide GnRH I (D43). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: GnRH I; GnRH I (D43) Peptide; Progonadoliberin I; Progonadoliberin-1; GNRH; GRH; LHRH; GNRH1; GnRHI blocking peptide

• Specificity: This peptide can be used with studies using MBS3003156 GnRH I (D43) pAb.
• Purity/Purification: Synthetic peptide GnRH I (D43). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 92

• Applicable Applications for GnRHI blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for GnRHI blocking peptide

Human reproduction is controlled by the hypothalaic-pituitary gonadal axislaid down early in fetal development. Luteinizing hormone releasing hormone (LHRH), also known as gonadotropin releasing hormone (GnRH), luliberin, gonadorelin or GnRH-associated peptide, is a decapeptide that is an important molecule in the hypothalamic-pituitary-gonadal axis control circuit. GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

NCBI and Uniprot Product Information

• NCBI GI #: 133908612
• NCBI GeneID: 2796
• NCBI Accession #: NP_001076580.1
• NCBI GenBank Nucleotide #: NP_001076580.1
• UniProt Accession #: P01148
• NCBI Official Full Name: progonadoliberin-1 isoform 2 preproprotein
• NCBI Official Synonym Full Names: gonadotropin releasing hormone 1
• NCBI Official Symbol: GNRH1
• NCBI Official Synonym Symbols: GRH; GNRH; LHRH; LNRH
• NCBI Protein Information: progonadoliberin-1
• UniProt Protein Name: Progonadoliberin-1
• UniProt Gene Name: GNRH1
• UniProt Synonym Gene Names: GNRH; GRH; LHRH; GnRH-I; LH-RH I
• UniProt Entry Name: GON1_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Uniprot Description

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia