Human guanine nucleotide binding protein-like 3 (nucleolar) -like ELISA Kit | GNL3L elisa kit

Human Guanine nucleotide-binding protein-like 3-like protein, GNL3L ELISA Kit

Cat. Num. AAA9316182

• Reactivity: Human
• Synonyms: guanine nucleotide binding protein-like 3 (nucleolar) -like; Human Guanine nucleotide-binding protein-like 3-like protein; GNL3L ELISA Kit; Human Guanine nucleotide-binding protein-like 3-like protein (GNL3L) ELISA kit; RP11-353K22.1; FLJ10613; OTTHUMP00000023374; novel GTPase; GNL3L elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 296317324
• NCBI GeneID: 54552
• NCBI Accession #: NP_001171748.1
• NCBI GenBank Nucleotide #: NM_001184819.1
• UniProt Accession #: Q9NVN8
• Molecular Weight: 65,573 Da
• NCBI Official Full Name: guanine nucleotide-binding protein-like 3-like protein
• NCBI Official Synonym Full Names: guanine nucleotide binding protein-like 3 (nucleolar)-like
• NCBI Official Symbol: GNL3L
• NCBI Protein Information: guanine nucleotide-binding protein-like 3-like protein; novel GTPase
• UniProt Protein Name: Guanine nucleotide-binding protein-like 3-like protein
• Protein Family: Guanine nucleotide-binding protein-like 3-like protein
• UniProt Gene Name: GNL3L
• UniProt Entry Name: GNL3L_HUMAN

NCBI Description

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: nucleoplasm; mitochondrion; membrane; cytoplasm; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: metabolic process; ribosome biogenesis and assembly