Structure
GNE 0723, Inhibitor | GNE0723, inhibitor
GNE 0723
Purity
98.00%
Synonyms
GNE 0723; GNE0723; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C16H8ClF6N5OS
SMILES
N#C[C@H]1[C@H](C2=C(C(F)(F)F)SC3=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC(N32)=O)C1
CAS Number
1883518-31-7
Target & IC50
GluN2A: ic50 21nM (EC50)
GluN2C: ic50 7.4uM (EC50)
GluN2D: ic50 6.2uM (EC50)
GluN2C: ic50 7.4uM (EC50)
GluN2D: ic50 6.2uM (EC50)
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for GNE0723, inhibitor
GNE 0723 is annMDAR brain permeable positive allosteric modulator (EC50: 21nM for GluN2A; 7.4 and 6.2uM for GluN2C and GluN2D, respectively).
References
Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of nMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of nMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of nMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
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Product Notes
The GNE0723 (Catalog #AAA5754913) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GNE 0723, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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