Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne) Recombinant Protein | Gne recombinant protein

Recombinant Rat Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne)

Cat. Num. AAA1063044

• Gene Names: Gne; Uae1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne); Recombinant Rat Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne); Gne recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-722, Full length protein
• Sequence: MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPAFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKCKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERISLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPQEGVVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAAMAERKFGQGKGQENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNVKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVRDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIH
• Sequence Length: 722

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Gne recombinant protein

This protein is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 16758602
• NCBI GeneID: 114711
• NCBI Accession #: NP_446217.1
• NCBI GenBank Nucleotide #: NM_053765.2
• UniProt Accession #: O35826
• Molecular Weight: 79,227 Da
• NCBI Official Full Name: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
• NCBI Official Synonym Full Names: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
• NCBI Official Symbol: Gne
• NCBI Official Synonym Symbols: Uae1
• NCBI Protein Information: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
• UniProt Protein Name: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
• Protein Family: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
• UniProt Gene Name: Gne
• UniProt Synonym Gene Names: Glcne

NCBI Description

bifunctional enzyme, catalyzes the first two steps of biosynthesis of Neu5Ac (UDP-GlcNAc 2-epimerase and ManNAc kinase), precursor of sialic acids [RGD, Feb 2006]

Uniprot Description

Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development ().