Human guanine nucleotide binding protein (G protein) , alpha activating activity polypeptide O ELISA Kit | GNAO1 elisa kit
Human Guanine nucleotide-binding protein G, GNAO1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); G protein
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: neuron projection; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding
Biological Process: response to drug; negative regulation of calcium ion transport; metabolic process; response to morphine; locomotory behavior; regulation of heart contraction; G-protein signaling, coupled to cAMP nucleotide second messenger; response to hydrogen peroxide; muscle contraction; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; neurite development; aging; positive regulation of GTPase activity
Disease: Epileptic Encephalopathy, Early Infantile, 17
Research Articles on GNAO1
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Product Notes
The Human GNAO1 gnao1 (Catalog #AAA9327322) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327322 ELISA Kit recognizes Human GNAO1. It is sometimes possible for the material contained within the vial of "guanine nucleotide binding protein (G protein) , alpha activating activity polypeptide O, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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