Glycine-N-Acyltransferase Recombinant Protein | GLYAT recombinant protein

Recombinant Human Glycine-N-Acyltransferase

Cat. Num. AAA145064

• Gene Names: GLYAT; CAT; GAT; ACGNAT
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Glycine-N-Acyltransferase; Recombinant Human Glycine-N-Acyltransferase; GLYAT Human; Glycine-N-Acyltransferase Human Recombinant; Glycine-N-acyltransferase; ACGNAT; GAT; CAT; AAc; HRP-1(CLP); Acyl-CoA: glycine amino acid N-acyltransferase; EC 2.3.1.13; GLYAT recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: GLYAT protein (0.5mg/ml) is supplied in 20mM Tris-HCl, pH-8, 1mM DTT and 20% Glycerol.; GLYAT is supplied as a sterile filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MMLPLQGAQM LQMLEKSLRK SLPASLKVYG TVFHINHGNP FNLKAVVDKW PDFNTVVVCP QEQDMTDDLD HYTNTYQIYS KDPQNCQEFL GSPELINWKQ HLQIQSSQPS LNEAIQNLAA IKSFKVKQTQ RILYMAAETA KELTPFLLKS KILSPSGGKP KAINQEMFKL SSMDVTHAHL VNKFWHFGGN ERSQRFIERC IQTFPTCCLL GPEGTPVCWD LMDQTGEMRM AGTLPEYRLH GLVTYVIYSH AQKLGKLGFP VYSHVDYSNE AMQKMSYTLQ HVPIPRSWNQ WNCVPL.
• Sequence Length: 163

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for GLYAT recombinant protein

Description: GLYAT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-296) and having a molecular mass of 36.0 kDa.The GLYAT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: GLYAT is a mitochondrial acyltransferase that conjugates glycine with acyl-CoA substrates in the mitochondria. GLYAT is vital to the detoxification of endogenous and xenobiotic acyl-CoA's.

Product Categories/Family for GLYAT recombinant protein

Enzymes; Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 111038143
• NCBI GeneID: 10249
• NCBI Accession #: NP_005829.3
• NCBI GenBank Nucleotide #: NM_005838.3
• UniProt Accession #: Q6IB77; O14833; Q96QK7
• Molecular Weight: 18,506 Da
• NCBI Official Full Name: glycine N-acyltransferase isoform b
• NCBI Official Synonym Full Names: glycine-N-acyltransferase
• NCBI Official Symbol: GLYAT
• NCBI Official Synonym Symbols: CAT; GAT; ACGNAT
• NCBI Protein Information: glycine N-acyltransferase; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; aralkyl-CoA N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; glycine N-benzoyltransferase
• UniProt Protein Name: Glycine N-acyltransferase
• Protein Family: Glycine N-acyltransferase
• UniProt Gene Name: GLYAT
• UniProt Synonym Gene Names: ACGNAT; CAT; GAT; AAc
• UniProt Entry Name: GLYAT_HUMAN

NCBI Description

The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GLYAT: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Belongs to the glycine N-acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.13; Mitochondrial; EC 2.3.1.71; Transferase

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: glycine N-benzoyltransferase activity; glycine N-acyltransferase activity; transferase activity, transferring acyl groups

Biological Process: glycine metabolic process; acyl-CoA metabolic process; response to toxin; xenobiotic metabolic process; monocarboxylic acid metabolic process