Glycerol uptake facilitator protein (glpF) Recombinant Protein | glpF recombinant protein
Recombinant Escherichia coli Glycerol uptake facilitator protein (glpF)
NCBI and Uniprot Product Information
NCBI Description
The glycerol facilitator, GlpF, allows the facilitated diffusion of glycerol across the inner membrane for utilization inside the cell. [More information is available at EcoCyc: EG10396].
Uniprot Description
Function: Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols.
Cofactor: Binds 2 magnesium ions per subunit.
Subunit structure: Homotetramer
Potential.
Subcellular location: Cell inner membrane; Multi-pass membrane protein Ref.9.
Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Miscellaneous: The remarkable property of effective water conductance combined with a strict exclusion of all ions including protons is mediated by two conserved asparagines which force a central water molecule to serve strictly as a hydrogen bond donor to its neighboring water molecules. Assisted by the electrostatic potential generated by two half-membrane spanning loops, this dictates opposite orientations of water molecules in the two halves of the channel, and thus prevents the formation of a "proton wire", while permitting rapid water diffusion.
Sequence similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]
Research Articles on glpF
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Product Notes
The glpF glpf (Catalog #AAA1252512) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-281. The amino acid sequence is listed below: MSQTSTLKGQ CIAEFLGTGL LIFFGVGCVA ALKVAGASFG QWEISVIWGL GVAMAIYLTA GVSGAHLNPA VTIALWLFAC FDKRKVIPFI VSQVAGAFCA AALVYGLYYN LFFDFEQTHH IVRGSVESVD LAGTFSTYPN PHINFVQAFA VEMVITAILM GLILALTDDG NGVPRGPLAP LLIGLLIAVI GASMGPLTGF AMNPARDFGP KVFAWLAGWG NVAFTGGRDI PYFLVPLFGP IVGAIVGAFA YRKLIGRHLP CDICVVEEKE TTTPSEQKAS L. It is sometimes possible for the material contained within the vial of "Glycerol uptake facilitator protein (glpF), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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