Probable glutamine synthetase 2 (glnA) Recombinant Protein | glnA recombinant protein
Recombinant Mycobacterium smegmatis Probable glutamine synthetase 2 (glnA)
NCBI and Uniprot Product Information
Uniprot Description
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
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Product Notes
The glnA glna (Catalog #AAA1011423) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-446, Full length protein. The amino acid sequence is listed below: MDRQKEFVLR TLEERDIRFV RLWFTDVLGY LKSVAIAPAE LEGAFEEGIG FDGSSIEGFA RVFESDTVAR PDPSTFQVLP WKTSDGNHYS ARMFCDITMP DGSPSWADSR HVLRRQLAKA SDLGFTCYVH PEIEFFLLKP GPNDGTPPEP ADNGGYFDQA VHDAAPNFRR HAIEALEQMG ISVEFSHHEG APGQQEIDLR YADALSMADN VMTFRYLVKE VALADGVRAS FMPKPFAEHP GSAMHTHMSL FEGDTNAFHS PDDPLQLSDV AKSFIAGILE HANEISAVTN QWVNSYKRLV HGGEAPTAAS WGAANRSALV RVPMYTPHKV SSRRVEVRSP DSACNPYLTF AVLLAAGLRG VEKGYVLGPQ AEDNVWSLTQ EERRAMGYRE LPTSLGNALE SMENSELVAE ALGEHVFDYF LRNKRSEWEN YRSHVTPYEL KNYLSL. It is sometimes possible for the material contained within the vial of "Probable glutamine synthetase 2 (glnA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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