Mouse GLIS family zinc finger 3 ELISA Kit | GLIS3 elisa kit
Mouse Zinc finger protein GLIS3, GLIS3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Description
GLIS3: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. Defects in GLIS3 are a cause of diabetes mellitus neonatal with congenital hypothyroidism (NDH). NDH is a neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; C2H2-type zinc finger protein
Cellular Component: nucleoplasm; Golgi apparatus; nucleus
Molecular Function: nucleic acid binding; DNA binding; metal ion binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Research Articles on GLIS3
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Product Notes
The Mouse GLIS3 glis3 (Catalog #AAA9334248) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334248 ELISA Kit recognizes Mouse GLIS3. It is sometimes possible for the material contained within the vial of "GLIS family zinc finger 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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