GLI2 Blocking Peptide | GLI2 (HGNC:4318) blocking peptide

GLI2 Blocking Peptide (C-term)

• Gene Names: GLI2; CJS; HPE9; PHS2; THP1; THP2
• Synonyms: GLI2; GLI2 Blocking Peptide (C-term); Zinc finger protein GLI2; GLI family zinc finger protein 2; Tax helper protein; GLI2 (HGNC:4318) blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 1287-1301 of HUMAN GLI2 (HGNC:4318)
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1586

• Cellular Location: Nucleus. Cytoplasm. Note: In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus Isoform 2: Nucleus
• Tissue Location: Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GLI2 (HGNC:4318) blocking peptide

Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. May play a role during embryogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 215274258
• NCBI GeneID: 2736
• UniProt Accession #: P10070; O60252; O60253; O60254; O60255; Q15590; Q15591; Q4JHT4
• Molecular Weight: 86,482 Da
• NCBI Official Full Name: Zinc finger protein GLI2
• NCBI Official Synonym Full Names: GLI family zinc finger 2
• NCBI Official Symbol: GLI2
• NCBI Official Synonym Symbols: CJS; HPE9; PHS2; THP1; THP2
• NCBI Protein Information: zinc finger protein GLI2
• UniProt Protein Name: Zinc finger protein GLI2
• UniProt Gene Name: GLI2
• UniProt Entry Name: GLI2_HUMAN

NCBI Description

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Uniprot Description

Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).