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Growth Hormone Releasing Hormone Receptor Recombinant Protein | GHRHR recombinant protein
Recombinant Growth Hormone Releasing Hormone Receptor (GHRHR)
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Uniprot Description
GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Cell development/differentiation; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: cell surface; cytoplasm; integral to membrane; nuclear inner membrane; nuclear matrix; nuclear outer membrane; plasma membrane; sarcolemma; secretory granule
Molecular Function: G-protein coupled receptor activity; growth factor binding; growth hormone-releasing hormone receptor activity; peptide hormone binding; protein binding
Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell maturation; cell surface receptor linked signal transduction; cellular response to insulin stimulus; determination of adult life span; G-protein signaling, adenylate cyclase activating pathway; growth hormone secretion; hormone metabolic process; lactation; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of growth hormone secretion; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of protein metabolic process; regulation of steroid hormone receptor signaling pathway; reproductive process in a multicellular organism; response to estrogen stimulus; response to glucocorticoid stimulus; response to insulin stimulus; somatotropin secreting cell development; water homeostasis
Disease: Isolated Growth Hormone Deficiency, Type Ib
Research Articles on GHRHR
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Product Notes
The GHRHR ghrhr (Catalog #AAA2033102) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Growth Hormone Releasing Hormone Receptor can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the GHRHR ghrhr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HMHPECDF ITQLREDESA CLQAAEEMPN TTLGCPATWD GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG WSEPFPPYPV ACPVPLELLA EEESYFSTVK. It is sometimes possible for the material contained within the vial of "Growth Hormone Releasing Hormone Receptor, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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