Growth hormone receptor (Ghr) Recombinant Protein | Ghr recombinant protein

Recombinant Rat Growth hormone receptor (Ghr)

• Gene Names: Ghr; GHR/BP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Growth hormone receptor (Ghr); Recombinant Rat Growth hormone receptor (Ghr); Growth hormone receptor; GH receptor; Somatotropin receptorCleaved into the following chain:; 1. Growth hormone-binding protein; 2. GH-binding protein; 3. GHBP; Serum-binding protein; Ghr recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 19-265
• Sequence: FP GSGATPATLG KASPVLQRIN PSLRESSSGK PRFTKCRSPE LETFSCYWTE GDDHNLKVPG SIQLYYARRI AHEWTPEWKE CPDYVSAGAN SCYFNSSYTS IWIPYCIKLT TNGDLLDEKC FTVDEIVQPD PPIGLNWTLL NISLPGIRGD IQVSWQPPPS ADVLKGWIIL EYEIQYKEVN ETKWKTMSPI WSTSVPLYSL RLDKEHEVRV RSRQRSFEKY SEFSEVLRVT FPQMDTLAAC EEDFR
• Sequence Length: 247

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 8393434
• NCBI GeneID: 25235
• NCBI Accession #: NP_058790.1
• NCBI GenBank Nucleotide #: NM_017094.1
• UniProt Accession #: P16310; Q64236; Q80XW9
• Molecular Weight: 31,957 Da
• NCBI Official Full Name: growth hormone receptor
• NCBI Official Synonym Full Names: growth hormone receptor
• NCBI Official Symbol: Ghr
• NCBI Official Synonym Symbols: GHR/BP
• NCBI Protein Information: growth hormone receptor; GH receptor; somatotropin receptor; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; growth hormone receptor precursor splice variant D56
• UniProt Protein Name: Growth hormone receptor
• Protein Family: Growth hormone receptor
• UniProt Gene Name: Ghr
• UniProt Synonym Gene Names: GH receptor; GH-binding protein; GHBP
• UniProt Entry Name: GHR_RAT

NCBI Description

may play a role in chondrocyte differentiation and positive regulation of longitudinal bond growth and [RGD, Feb 2006]

Uniprot Description

GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: extracellular space; extrinsic to membrane; cell surface; mitochondrion; cell soma; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; receptor complex

Molecular Function: growth hormone receptor activity; protein homodimerization activity; peptide hormone binding; growth factor binding; SH2 domain binding; protein phosphatase binding; protein kinase binding

Biological Process: activation of JAK protein; response to peptide hormone stimulus; succinate metabolic process; oxaloacetate metabolic process; hormone-mediated signaling; activation of MAPK activity; response to glucocorticoid stimulus; response to hormone stimulus; positive regulation of JAK-STAT cascade; response to morphine; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; 2-oxoglutarate metabolic process; allantoin metabolic process; receptor internalization; creatinine metabolic process; response to food; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; citrate metabolic process; regulation of multicellular organism growth; valine metabolic process; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; response to cytokine stimulus; response to cycloheximide; positive regulation of cell differentiation; taurine metabolic process