Goat Growth Hormone Antibody ELISA Kit | GH elisa kit
Goat Growth Hormone Antibody ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Subunit structure: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain
By similarity. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity. Note: On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway
By similarity.Growth hormone-binding protein: Secreted
By similarity. Note: Complexed to a substantial fraction of circulating GH
By similarity.
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization
By similarity.
Post-translational modification: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2
By similarity. Ref.2On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization
By similarity.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain.
Research Articles on GH
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Product Notes
The Goat GH ghr (Catalog #AAA011850) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA011850 ELISA Kit recognizes Goat GH. It is sometimes possible for the material contained within the vial of "Growth Hormone Antibody, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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