Geranylgeranyl Diphosphate Synthase 1 Recombinant Protein | GGPS1 recombinant protein

Recombinant Human Geranylgeranyl Diphosphate Synthase 1

Cat. Num. AAA144098

• Gene Names: GGPS1; GGPPS; GGPPS1
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Geranylgeranyl Diphosphate Synthase 1; Recombinant Human Geranylgeranyl Diphosphate Synthase 1; GGPS1 Human; Geranylgeranyl Diphosphate Synthase 1 Human Recombinant; GGPPS; GGPPS1; GGPP synthetase; GGPS1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: GGPS1 Human recombinant (1mg/ml) protein solution contains 20mM Tris pH-8, 1mM DTT & 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE
• Sequence Length: 300

• Preparation and Storage: Store at 4°C if entire vial will be used within 2-4 weeks.; Store, frozen at -20°C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for GGPS1 recombinant protein

GGPS1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 320 amino acids (1-300 a.a.) and having a molecular mass of 37 kDa. The GGPS1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Product Categories/Family for GGPS1 recombinant protein

Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 83700220
• NCBI GeneID: 9453
• NCBI Accession #: NP_001032354.1
• NCBI GenBank Nucleotide #: NM_001037277.1
• UniProt Accession #: O95749; Q5T2C8; Q6NW19; A8MVQ8
• NCBI Official Full Name: geranylgeranyl pyrophosphate synthase
• NCBI Official Synonym Full Names: geranylgeranyl diphosphate synthase 1
• NCBI Official Symbol: GGPS1
• NCBI Official Synonym Symbols: GGPPS; GGPPS1
• NCBI Protein Information: geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPPSase; dimethylallyltranstransferase; farnesyltranstransferase; geranyltranstransferase
• UniProt Protein Name: Geranylgeranyl pyrophosphate synthase
• UniProt Gene Name: GGPS1
• UniProt Synonym Gene Names: GGPP synthase; GGPPSase
• UniProt Entry Name: GGPPS_HUMAN

NCBI Description

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: Transferase; Motility/polarity/chemotaxis; EC 2.5.1.1; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; EC 2.5.1.29

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol

Molecular Function: geranyltranstransferase activity; dimethylallyltranstransferase activity; farnesyltranstransferase activity; metal ion binding

Biological Process: isoprenoid metabolic process; geranylgeranyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; farnesyl diphosphate biosynthetic process; cholesterol biosynthetic process