GGPS1 recombinant protein

GGPS1 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121867

• Gene Names: GGPS1; GGPPS; GGPPS1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: GGPS1; GGPS1 Protein; Human; Recombinant (His Tag); Human GGPS1/GGPPS1 Protein (His Tag); GGPPS Protein; GGPPS1 Protein; geranylgeranyl diphosphate synthase 1; GGPS1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, 20% glycerol, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu300

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Met
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human GGPS1 (NP_001032354.1)(Met1-Glu300) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 83700220
• NCBI GeneID: 9453
• NCBI Accession #: NP_001032354.1
• NCBI GenBank Nucleotide #: NM_001037277.1
• UniProt Accession #: O95749; Q5T2C8; Q6NW19; A8MVQ8
• Molecular Weight: 28,423 Da
• NCBI Official Full Name: geranylgeranyl pyrophosphate synthase
• NCBI Official Synonym Full Names: geranylgeranyl diphosphate synthase 1
• NCBI Official Symbol: GGPS1
• NCBI Official Synonym Symbols: GGPPS; GGPPS1
• NCBI Protein Information: geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPPSase; dimethylallyltranstransferase; farnesyltranstransferase; geranyltranstransferase
• UniProt Protein Name: Geranylgeranyl pyrophosphate synthase
• UniProt Gene Name: GGPS1
• UniProt Synonym Gene Names: GGPP synthase; GGPPSase
• UniProt Entry Name: GGPPS_HUMAN

NCBI Description

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; EC 2.5.1.29; Motility/polarity/chemotaxis; EC 2.5.1.1

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol

Molecular Function: geranyltranstransferase activity; dimethylallyltranstransferase activity; farnesyltranstransferase activity; metal ion binding

Biological Process: isoprenoid metabolic process; geranylgeranyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; farnesyl diphosphate biosynthetic process; cholesterol biosynthetic process