Human glutamine-fructose-6-phosphate transaminase 1 ELISA Kit | GFPT1 elisa kit
Human Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1, GFPT1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
Uniprot Description
GFAT: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Homotetramer (Potential). Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.6.1.16; Amino Acid Metabolism - alanine, aspartate and glutamate; Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: cytosol
Molecular Function: amino acid binding; carbohydrate binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Biological Process: dolichol-linked oligosaccharide biosynthetic process; unfolded protein response; glucosamine biosynthetic process; glutamine metabolic process; fructose 6-phosphate metabolic process; post-translational protein modification; carbohydrate biosynthetic process; protein homotetramerization; response to sucrose stimulus; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; circadian regulation of gene expression; negative regulation of glycogen biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Acetylcholine Receptor Deficiency; Myasthenic Syndrome, Congenital, With Tubular Aggregates 1
Research Articles on GFPT1
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Product Notes
The Human GFPT1 gfpt1 (Catalog #AAA9336143) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336143 ELISA Kit recognizes Human GFPT1. It is sometimes possible for the material contained within the vial of "glutamine-fructose-6-phosphate transaminase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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