Porcine Glutamate Dehydrogenase 1 ELISA Kit | GDH elisa kit
Porcine Glutamate Dehydrogenase 1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]
Uniprot Description
GLUD1: May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Homohexamer. Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein type: Energy Metabolism - nitrogen; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 1.4.1.3; Oxidoreductase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm
Molecular Function: identical protein binding; protein binding; glutamate dehydrogenase activity; GTP binding; glutamate dehydrogenase [NAD(P)+] activity; ADP binding; ATP binding
Biological Process: glutamate catabolic process; substantia nigra development; positive regulation of insulin secretion; glutamine metabolic process; glutamate biosynthetic process; amino acid biosynthetic process
Disease: Hyperinsulinemic Hypoglycemia, Familial, 6
Research Articles on GDH
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Product Notes
The Porcine GDH glud1 (Catalog #AAA737648) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA737648 ELISA Kit recognizes Porcine GDH. It is sometimes possible for the material contained within the vial of "Glutamate Dehydrogenase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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