Guinea Pig Growth Differentiation Factor 2 ELISA Kit | GDF2 elisa kit
Guinea pig Growth Differentiation Factor 2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]
Uniprot Description
GDF2: Could be involved in bone formation. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.22
Cellular Component: extracellular space
Molecular Function: protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; regulation of apoptosis; BMP signaling pathway; positive regulation of interleukin-8 production; positive regulation of endothelial cell differentiation; angiogenesis; vasculogenesis; positive regulation of BMP signaling pathway; ossification; negative regulation of blood vessel endothelial cell migration; patterning of blood vessels; osteoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of angiogenesis; positive regulation of angiogenesis; negative regulation of DNA replication; cartilage development; regulation of MAPKKK cascade; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of cell growth; cell development; growth
Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5
Research Articles on GDF2
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Product Notes
The Guinea Pig GDF2 gdf2 (Catalog #AAA723987) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA723987 ELISA Kit recognizes Guinea Pig GDF2. It is sometimes possible for the material contained within the vial of "Growth Differentiation Factor 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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