GDF-15 recombinant protein

Human CellExp GDF-15; Human Recombinant

Cat. Num. AAA8400647

• Gene Names: GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
• Purity: >95% by SDS-PAGE
• Synonyms: GDF-15; Human CellExp GDF-15; Human Recombinant; Growth Differentiation Factor 15; MIC-1; Macrophage Inhibitory Cytokine 1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; GDF-15 recombinant protein

• Host: HEK293 cells
• Specificity: A protein with functions in regulating inflammatory and apoptotic pathways
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Lyophilized protein
• Sequence: Ala195-Ile308

• Source: Human
• Tag: His-tag at the C-terminus
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening. Reconstitute in sterile 4mM acetic acid. Do not vortex.; Shipping: Gel Pack; Shelf Life: Est.~12 months; Country of Origin: USA

SDS-Page

Related Product Information for GDF-15 recombinant protein

Growth Differentiation Factor 15 (GDF15), also known as Macrophage inhibitory cytokine 1 (MIC-1), is a protein belonging to the TGF-beta superfamily. Like other proteins in the superfamily, it is expressed as a large precursor protein and cleaved at an (RxxR) furin-like cleavage site to release the mature protein. GDF15 is highly expressed in mammalian tissue with higher levels in the placenta and brain and lower levels in the kidney, prostate, colon. Its expression is tightly regulated and often induced in response to cellular stress. Additionally, GDF15 has been shown to have various functions, including inhibition of Tumor Necrosis Factor alpha (TNF-alpha) production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. Some studies have also implicated GDF15 serum levels to have a strong association with many diseases like cancer, cardiovascular diseases, and obesity, and could potentially serve as a reliable biomarker for disease progression.

Product Categories/Family for GDF-15 recombinant protein

Web Categories; Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Adipokines; Proteins and Enzymes; Proteins and Enzymes (A-Z); Growth Factors; Signaling Pathways; Adipokine Signaling; Human cell expressed recombinant proteins; Adipokines; Diabe

NCBI and Uniprot Product Information

• NCBI GI #: 153792495
• NCBI GeneID: 9518
• NCBI Accession #: NP_004855.2
• NCBI GenBank Nucleotide #: NM_004864.2
• UniProt Accession #: Q99988; O14629; P78360; Q9BWA0; Q9NRT0
• Molecular Weight: 34,140 Da
• NCBI Official Full Name: growth/differentiation factor 15
• NCBI Official Synonym Full Names: growth differentiation factor 15
• NCBI Official Symbol: GDF15
• NCBI Official Synonym Symbols: PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
• NCBI Protein Information: growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonster
• UniProt Protein Name: Growth/differentiation factor 15
• UniProt Gene Name: GDF15
• UniProt Synonym Gene Names: MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1
• UniProt Entry Name: GDF15_HUMAN

NCBI Description

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

Uniprot Description

GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; cell-cell signaling; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; signal transduction; cell development