Envelope glycoprotein B (gB) Recombinant Protein | UL27 recombinant protein

Recombinant Human herpesvirus 2 Envelope glycoprotein B (gB)

Cat. Num. AAA1138391

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Envelope glycoprotein B (gB); Recombinant Human herpesvirus 2 Envelope glycoprotein B (gB); Recombinant Envelope glycoprotein B (gB); Envelope glycoprotein B; gB; gB-2 gB2; UL27 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 23-279aa; Partial
• Sequence: APAAPAAPRASGGVAATVAANGGPASRPPPVPSPATTKARKRKTKKPPKRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINTKGVCRSTAKYVRNNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPY

• Species: Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
• Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

SDS-Page

Related Product Information for UL27 recombinant protein

Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.

NCBI and Uniprot Product Information

• NCBI GI #: 9629297
• NCBI GeneID: 1487312
• NCBI Accession #: NP_044497.1
• NCBI GenBank Nucleotide #: NC_001798.1
• UniProt Accession #: P08666; P89450
• Molecular Weight: 44.4 kDa
• NCBI Official Full Name: envelope glycoprotein B
• NCBI Official Symbol: UL27
• NCBI Protein Information: type 1 membrane protein; contains a signal peptide; possible membrane fusogen; binds cell surface heparan sulphate; envelope glycoprotein B
• UniProt Protein Name: Envelope glycoprotein B
• Protein Family: Envelope glycoprotein
• UniProt Gene Name: gB
• UniProt Synonym Gene Names: gB
• UniProt Entry Name: GB_HHV2H

Uniprot Description

Function: Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).

Subunit structure: Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gD. Interacts with gH/gL heterodimer. Associates with the gB-gH/gL-gD complex

By similarity.

Subcellular location: Virion membrane; Single-pass type I membrane protein

By similarity. Host cell membrane; Single-pass type I membrane protein

By similarity. Host endosome membrane; Single-pass type I membrane protein

By similarity. Host Golgi apparatus membrane; Single-pass type I membrane protein

By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN)

By similarity.

Sequence similarities: Belongs to the herpesviridae glycoprotein B family.