Human cyclin G associated kinase ELISA Kit | GAK elisa kit
Human Cyclin-G-associated kinase, GAK ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Description
GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Cell cycle regulation; Protein kinase, Other; Other group; NAK family
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: Golgi apparatus; focal adhesion; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: endoplasmic reticulum organization and biogenesis; epidermal cell differentiation; cell cycle; forebrain morphogenesis; protein amino acid phosphorylation; Golgi organization and biogenesis; cell development
Research Articles on GAK
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Product Notes
The Human GAK gak (Catalog #AAA9317726) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317726 ELISA Kit recognizes Human GAK. It is sometimes possible for the material contained within the vial of "cyclin G associated kinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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