Frizzled-8 (FZD8) Recombinant Protein | FZD8 recombinant protein
Recombinant Human Frizzled-8 (FZD8)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10p11.21
Cellular Component: Golgi apparatus; integral to membrane
Molecular Function: G-protein coupled receptor activity; PDZ domain binding; protein binding; receptor binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding
Biological Process: angiogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; positive regulation of JNK activity; positive regulation of transcription from RNA polymerase II promoter; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin
Research Articles on FZD8
Similar Products
Product Notes
The FZD8 fzd8 (Catalog #AAA7015423) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 28-694aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the FZD8 fzd8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ASAKELACQE ITVPLCKGIG YNYTYMPNQF NHDTQDEAGL EVHQFWPLVE IQCSPDLKFF LCSMYTPICL EDYKKPLPPC RSVCERAKAG CAPLMRQYGF AWPDRMRCDR LPEQGNPDTL CMDYNRTDLT TAAPSPPRRL PPPPPGEQPP SGSGHGRPPG ARPPHRGGGR GGGGGDAAAP PARGGGGGGK ARPPGGGAAP CEPGCQCRAP MVSVSSERHP LYNRVKTGQI ANCALPCHNP FFSQDERAFT VFWIGLWSVL CFVSTFATVS TFLIDMERFK YPERPIIFLS ACYLFVSVGY LVRLVAGHEK VACSGGAPGA GGAGGAGGAA AGAGAAGAGA GGPGGRGEYE ELGAVEQHVR YETTGPALCT VVFLLVYFFG MASSIWWVIL SLTWFLAAGM KWGNEAIAGY SQYFHLAAWL VPSVKSIAVL ALSSVDGDPV AGICYVGNQS LDNLRGFVLA PLVIYLFIGT MFLLAGFVSL FRIRSVIKQQ DGPTKTHKLE KLMIRLGLFT VLYTVPAAVV VACLFYEQHN RPRWEATHNC PCLRDLQPDQ ARRPDYAVFM LKYFMCLVVG ITSGVWVWSG KTLESWRSLC TRCCWASKGA AVGGGAGATA AGGGGGPGGG GGGGPGGGGG PGGGGGSLYS DVSTGLTWRS GTASSVSYPK QMPLSQV. It is sometimes possible for the material contained within the vial of "Frizzled-8 (FZD8), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
