Rat Frizzled-1 ELISA Kit | Fzd1 elisa kit

Rat Frizzled-1 ELISA Kit

Cat. Num. AAA2880673

• Reactivity: Rat
• Synonyms: Frizzled-1; Rat Frizzled-1 ELISA Kit; Fz-1; rFz1; Fzd1; Fzd1 elisa kit

• Reactivity: Rat
• Sequence Length: 641

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 17432926
• NCBI GeneID: 58868
• UniProt Accession #: Q08463
• Molecular Weight: 71,027 Da
• NCBI Official Full Name: Frizzled-1
• NCBI Official Synonym Full Names: frizzled class receptor 1
• NCBI Official Symbol: Fzd1
• NCBI Protein Information: frizzled-1
• UniProt Protein Name: Frizzled-1
• Protein Family: Frizzled
• UniProt Gene Name: Fzd1
• UniProt Synonym Gene Names: Fz-1; rFz1
• UniProt Entry Name: FZD1_RAT

NCBI Description

G-protein-coupled receptor; may mediate signals required for normal morphogenesis and differentiation; may play a role in bone resorption [RGD, Feb 2006]

Uniprot Description

FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, Fz/Smo family; Membrane protein, integral

Cellular Component: cell surface; focal adhesion; integral to membrane; neuron projection; plasma membrane

Molecular Function: frizzled binding; G-protein coupled receptor activity; identical protein binding; PDZ domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; Wnt receptor activity; Wnt-protein binding

Biological Process: alveolus development; cell-cell signaling; epithelial cell differentiation; G-protein coupled receptor protein signaling pathway; hard palate development; negative regulation of BMP signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of osteoblast differentiation; response to drug; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin