Human Frizzled-1 ELISA Kit | FZD1 elisa kit

Human Frizzled-1 ELISA Kit

Cat. Num. AAA2880124

• Reactivity: Human
• Synonyms: Frizzled-1; Human Frizzled-1 ELISA Kit; Fz-1; hFz1; FzE1; FZD1; FZD1 elisa kit

• Reactivity: Human
• Sequence Length: 647

• Assay Type: Sandwich
• Detection Range: 0.78-50 ng/mL
• Sensitivity: 0.34 ng/ml
• Intra-Assay CV: <=4.6%
• Inter-Assay CV: <=8.3%
• Recovery: 95%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4503825
• NCBI GeneID: 8321
• NCBI Accession #: NP_003496.1
• NCBI GenBank Nucleotide #: NM_003505.1
• UniProt Accession #: Q9UP38; O94815; Q549T8; A4D1E8
• Molecular Weight: 71,158 Da
• NCBI Official Full Name: frizzled-1
• NCBI Official Synonym Full Names: frizzled class receptor 1
• NCBI Official Symbol: FZD1
• NCBI Protein Information: frizzled-1
• UniProt Protein Name: Frizzled-1
• Protein Family: Frizzled
• UniProt Gene Name: FZD1
• UniProt Synonym Gene Names: Fz-1; hFz1
• UniProt Entry Name: FZD1_HUMAN

NCBI Description

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

Uniprot Description

FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, Fz/Smo family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: cell surface; focal adhesion; integral to membrane; neuron projection; plasma membrane

Molecular Function: frizzled binding; G-protein coupled receptor activity; PDZ domain binding; protein binding; receptor binding; Wnt receptor activity; Wnt-protein binding

Biological Process: alveolus development; cell-cell signaling; epithelial cell differentiation; G-protein coupled receptor protein signaling pathway; hard palate development; negative regulation of BMP signaling pathway; negative regulation of transcription, DNA-dependent; neuron differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of osteoblast differentiation; response to drug; synaptogenesis; Wnt receptor signaling pathway through beta-catenin