DNA translocase FtsK (ftsK) Recombinant Protein | ftsK recombinant protein
Recombinant Coxiella burnetii DNA translocase FtsK (ftsK)
NCBI and Uniprot Product Information
Uniprot Description
Function: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif
By similarity.
Subunit structure: Homohexamer. Forms a ring that surrounds DNA
By similarity.
Subcellular location: Cell inner membrane; Multi-pass membrane protein
By similarity. Note: Located at the septum
By similarity.
Domain: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase
By similarity.
Sequence similarities: Belongs to the FtsK/SpoIIIE/SftA family.Contains 1 FtsK domain.
Sequence caution: The sequence AAO90700.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Product Notes
The ftsK ftsk (Catalog #AAA1110488) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-778. The amino acid sequence is listed below: MGRRKGKKSA KETGVLLRRH LRYRLREGCF ILALAFSAFL FIALLSYHRS DPGWSHSIVV KHVANLTGEA GAWLSDFTLY MVGYLAYIFP LMVAFAAWVF FRNRHEEQDI PTKWPLLILR AVGFLLILLA GSALAAIHLG TLDANLPYNG GGIIGVVMAK SLFPIFNTAG TSLILIAFLL IGITLFTGLS WFQFLELLGK NAIKFTKFCA IRLGAISWKD LFLSLLPSQD KREAVTVPKI KRVEPDLVPD ALDMISTPKI AERPKLEIID HEFKTPRFKG SAILPELSLL DKPSQDHTLS YSEEELQQKS REVELRLADF GIQAKVVAVH PGPVVTRFEL QLAAGTKASR VTNLAKDLAR SLSVISVRIV EVIPGKSVIG LELPNKNREV VTIYEVLATK QYQNARSSLT LALGKDIGGH PVIVDLAKMP HLLVAGTTGS GKSVSLNAML LSLLYKSTPQ QLRLILIDPK MLELSVYEGI PHLLTPVVTD MKDAAAALRW CVVEMERRYR LMASLGVRNI LGYNAKVKEA IEAGAPLLDP LQAAAEGKPP ELQELPQLVV IADEFADMMV VVGKKVETLI VRLAQKARAA GIHLIFATQR PSVDVITGLI KANIPTRVAF QVSSKIDSRT ILDQQGAEQL LGHGDLLYLA PGSGVPVRVH GPYVKDEEVH RVAEYLRESS EPNYVEGILD EMGAQDLSGF VEAALGGGSE EGGESDPLYD EAVEAVIRSR RVSVSSIQRR FKIGYNRAAR IVEAMEAAGV VSPMENNGAR EVLAPSKE. It is sometimes possible for the material contained within the vial of "DNA translocase FtsK (ftsK), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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