Human fat mass and obesity associated ELISA Kit | FTO elisa kit
Human Alpha-ketoglutarate-dependent dioxygenase FTO, FTO ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Uniprot Description
FTO: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD). A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years. Belongs to the fto family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: nuclear speck; nucleus
Molecular Function: ferrous iron binding; DNA-N1-methyladenine dioxygenase activity
Biological Process: DNA dealkylation; RNA repair; regulation of multicellular organism growth; thermoregulation
Disease: Growth Retardation, Developmental Delay, Coarse Facies, And Early Death
Research Articles on FTO
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Product Notes
The Human FTO fto (Catalog #AAA9326824) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326824 ELISA Kit recognizes Human FTO. It is sometimes possible for the material contained within the vial of "fat mass and obesity associated, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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