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Follistatin Like Protein 3 Recombinant Protein | FSTL3 recombinant protein
Recombinant Follistatin Like Protein 3 (FSTL3)
VMGSEDS VPGGVCWLQQ GREATCSLVLKTRVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGVECGPGKACRM LGGRPHCECV PNCEGLPAGF QVCGSDGATY RDECELRTARCRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPVPSNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAEEEENFV
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
Accurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions
NCBI Description
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Secreted, signal peptide; Secreted; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; extracellular region; nucleus; secretory granule
Molecular Function: protein binding; fibronectin binding; activin binding
Biological Process: negative regulation of osteoclast differentiation; ossification; transcription, DNA-dependent; adrenal gland development; male gonad development; negative regulation of BMP signaling pathway; regulation of transcription from RNA polymerase II promoter; negative regulation of activin receptor signaling pathway; positive regulation of cell-cell adhesion; spermatogenesis; hemopoietic progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; kidney development; lung development
Research Articles on FSTL3
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Product Notes
The FSTL3 fstl3 (Catalog #AAA2030084) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Follistatin Like Protein 3 (FSTL3) reacts with Mus musculus (Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's Follistatin Like Protein 3 can be used in a range of immunoassay formats including, but not limited to, Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.). Researchers should empirically determine the suitability of the FSTL3 fstl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.VMGSEDS VPGGVCWLQQ GREATCSLVL KTRVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV ECGPGKACRM LGGRPHCECV PNCEGLPAGF QVCGSDGATY RDECELRTAR CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV PSNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE EEENFV. It is sometimes possible for the material contained within the vial of "Follistatin Like Protein 3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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