Human Flt-3 Ligand ELISA Kit | FLT3LG elisa kit

Flt-3 Ligand (Human) OmniKine ELISA Kit

Cat. Num. AAA9501949

• Gene Names: FLT3LG; FL; FLG3L; FLT3L
• Reactivity: Human
• Synonyms: Flt-3 Ligand; Flt-3 Ligand (Human) OmniKine ELISA Kit; Fms-related tyrosine kinase 3 ligand; SL cytokine; FLT3LG elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human Flt-3L ELISA is capable of recognizing both recombinant and naturally produced Human Flt-3L proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: FGF-5, Flt-1/Fc, IL-8, PlGF, TNF-alpha, VEGF121, VEGF165; Murine: Flt-3L, IL-5
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 235

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human Flt-3 Ligand ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Flt-3 Ligand proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 325197197
• NCBI GeneID: 2323
• NCBI Accession #: NP_001191431.1
• NCBI GenBank Nucleotide #: NM_001204502.1
• UniProt Accession #: P49771; Q05C96; A0AVC2; B9EGH2
• Molecular Weight: 17,290 Da
• NCBI Official Full Name: fms-related tyrosine kinase 3 ligand isoform 1
• NCBI Official Synonym Full Names: fms related tyrosine kinase 3 ligand
• NCBI Official Symbol: FLT3LG
• NCBI Official Synonym Symbols: FL; FLG3L; FLT3L
• NCBI Protein Information: fms-related tyrosine kinase 3 ligand
• UniProt Protein Name: Fms-related tyrosine kinase 3 ligand
• Protein Family: Fms-related tyrosine kinase
• UniProt Gene Name: FLT3LG
• UniProt Synonym Gene Names: Flt3 ligand; Flt3L

NCBI Description

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

Uniprot Description

FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular region; extracellular space; integral component of membrane; membrane

Molecular Function: cytokine activity; protein homodimerization activity; receptor binding; receptor tyrosine kinase binding

Biological Process: embryonic hemopoiesis; homeostasis of number of cells within a tissue; lymphocyte differentiation; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of myoblast differentiation; positive regulation of natural killer cell differentiation; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of myeloid dendritic cell activation; signal transduction