FLOT1 recombinant protein

Recombinant Human FLOT1 protein, N- His Tag

Cat. Num. AAA157462

• Purity: >90% as determined by SDS-PAGE
• Synonyms: FLOT1; Recombinant Human FLOT1 protein; N- His Tag; FLOT1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the human FLOT1 (Thr150~Ala427) was fused with the N-terminal His Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

SDS-Page

Product Categories/Family for FLOT1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 26006960
• NCBI GeneID: 10211
• UniProt Accession #: O75955; Q969J8; Q9UHW1; Q9UNV8; B4DVY7
• Molecular Weight: 42,080 Da
• NCBI Official Full Name: Flotillin-1
• NCBI Official Synonym Full Names: flotillin 1
• NCBI Official Symbol: FLOT1
• NCBI Protein Information: flotillin-1; integral membrane component of caveolae
• UniProt Protein Name: Flotillin-1
• Protein Family: Flotillin-like protein
• UniProt Gene Name: FLOT1
• UniProt Entry Name: FLOT1_HUMAN

NCBI Description

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

FLOT1: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. Belongs to the band 7/mec-2 family. Flotillin subfamily.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: signalosome; focal adhesion; membrane; lysosomal membrane; integral to membrane; melanosome; microtubule organizing center; caveola; flotillin complex; sarcolemma; endosome; lipid raft

Molecular Function: ionotropic glutamate receptor binding; protein binding; protease binding

Biological Process: extracellular matrix disassembly; axonogenesis; regulation of Rho protein signal transduction