Filamin A ELISA Kit | FLNA elisa kit
Filamin A Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Uniprot Description
FLNA: a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: actin cytoskeleton; cell soma; cortical cytoskeleton; cytoplasm; cytosol; dendritic shaft; extracellular exosome; extracellular matrix; extracellular region; filamentous actin; focal adhesion; intercellular junction; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; Z disc
Molecular Function: actin filament binding; cadherin binding; G-protein coupled receptor binding; GTPase binding; ion channel binding; kinase binding; mu-type opioid receptor binding; potassium channel regulator activity; protein binding; protein homodimerization activity; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; RNA binding; signal transducer activity; SMAD binding; small GTPase binding; transcription factor binding
Biological Process: actin crosslink formation; actin cytoskeleton reorganization; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cerebral cortex development; cytoplasmic sequestering of protein; establishment of protein localization; formation of radial glial scaffolds; mitotic spindle assembly; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of protein catabolic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase I promoter; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of integrin-mediated signaling pathway; positive regulation of neural precursor cell proliferation; positive regulation of neuron migration; positive regulation of potassium ion transmembrane transport; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription factor import into nucleus; protein localization to cell surface; protein localization to plasma membrane; protein stabilization; receptor clustering; regulation of cell migration; regulation of membrane repolarization during atrial cardiac muscle cell action potential; regulation of membrane repolarization during cardiac muscle cell action potential; semaphorin-plexin signaling pathway; wound healing, spreading of cells
Disease: Cardiac Valvular Dysplasia, X-linked; Fg Syndrome 2; Frontometaphyseal Dysplasia; Heterotopia, Periventricular, Ehlers-danlos Variant; Heterotopia, Periventricular, X-linked Dominant; Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-linked; Melnick-needles Syndrome; Otopalatodigital Syndrome, Type I; Otopalatodigital Syndrome, Type Ii; Terminal Osseous Dysplasia
Research Articles on FLNA
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Product Notes
The Human, Mouse, Rat FLNA flna (Catalog #AAA9500229) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500229 ELISA Kit recognizes Human, Mouse, Rat FLNA. It is sometimes possible for the material contained within the vial of "Filamin A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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