Human Fractalkine ELISA Kit | FKN; elisa kit

Fractalkine (Human) OmniKine ELISA Kit

Cat. Num. AAA9502041

• Gene Names: CX3CL1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
• Reactivity: Human
• Synonyms: Fractalkine; Fractalkine (Human) OmniKine ELISA Kit; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; NTT; SCYD1; FKN; elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human Fractalkine ELISA is capable of recognizing both recombinant and naturally produced Human Fractalkine proteins. The antigens listed below were tested at 500 ng/ml and did not exhibit significant cross-reactivity or interference.; Murine: Fractalkine (Chemokine domain aa 22-105), Fractalkine (Chemokine domain and mucin stalk), Fractalkine (Chemokine domain aa 25-105)
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 397

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 625-20000 pg/ml
• Sensitivity: 625-20000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human Fractalkine ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Fractalkine proteins within the range of 625-20000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4506857
• NCBI GeneID: 6376
• NCBI Accession #: NP_002987.1
• NCBI GenBank Nucleotide #: NM_002996.5
• UniProt Accession #: P78423; O00672
• Molecular Weight: 42,203 Da
• NCBI Official Full Name: fractalkine isoform 1
• NCBI Official Synonym Full Names: C-X3-C motif chemokine ligand 1
• NCBI Official Symbol: CX3CL1
• NCBI Official Synonym Symbols: NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
• NCBI Protein Information: fractalkine
• UniProt Protein Name: Fractalkine
• Protein Family: Fractalkine
• UniProt Gene Name: CX3CL1
• UniProt Synonym Gene Names: FKN; NTT; SCYD1

NCBI Description

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]

Uniprot Description

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell surface; extracellular region; extracellular space; integral component of membrane; plasma membrane

Molecular Function: CCR chemokine receptor binding; chemokine activity; CX3C chemokine receptor binding; integrin binding; protein binding; receptor binding

Biological Process: angiogenesis involved in wound healing; cell adhesion; chemotaxis; cytokine-mediated signaling pathway; defense response; G-protein coupled receptor signaling pathway; immune response; integrin activation; leukocyte adhesive activation; leukocyte chemotaxis; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; macrophage chemotaxis; monocyte chemotaxis; negative regulation of cell migration; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of transforming growth factor beta1 production