PPIase / FKBP7 recombinant protein
Recombinant Human PPIase / FKBP7 Protein (Fc tag)
Gene Names
FKBP7; FKBP23; PPIase
Purity
> 90 % as determined by SDS-PAGE
Synonyms
PPIase / FKBP7; Recombinant Human PPIase / FKBP7 Protein (Fc tag); FKBP7; FKBP23; PPIase / FKBP7 recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
221
Application Notes
The recombinant human FKBP7/Fc is a disulfide-linked homodimer. The reduced monomer comprises 436 amino acids and has a predicted molecular mass of 49.4 kDa. The apparent molecular mass of the protein is approximately 55kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Gln 24
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
Related Product Information for PPIase / FKBP7 recombinant protein
Background: PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family, PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
Description: A DNA sequence encoding the human FKBP7 (Q9Y680-2) (Met1-Gln218) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the human FKBP7 (Q9Y680-2) (Met1-Gln218) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,723 Da
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP7 isoform b
NCBI Official Synonym Full Names
FK506 binding protein 7
NCBI Official Symbol
FKBP7
NCBI Official Synonym Symbols
FKBP23; PPIase
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP7
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP7
UniProt Gene Name
FKBP7
UniProt Synonym Gene Names
FKBP23; PPIase FKBP7; 23 kDa FKBP; FKBP-23; FKBP-7
NCBI Description
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]
Uniprot Description
FKBP7: PPIases accelerate the folding of proteins during protein synthesis. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding; EC 5.2.1.8; Endoplasmic reticulum; Isomerase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: endoplasmic reticulum membrane
Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
