FK506 Binding Protein 1A Recombinant Protein | FKBP1A recombinant protein
Recombinant Mouse FK506 Binding Protein 1A
Sterile Filtered clear colorless solution.
NCBI and Uniprot Product Information
Uniprot Description
FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.
Protein type: EC 5.2.1.8; Isomerase
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nerve terminal; sarcoplasmic reticulum membrane; Z disc
Molecular Function: activin binding; drug binding; enzyme binding; FK506 binding; Hsp70 protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein homodimerization activity; signal transducer activity; SMAD binding; transforming growth factor beta receptor binding
Biological Process: cytokine and chemokine mediated signaling pathway; fibril organization and biogenesis; heart morphogenesis; muscle contraction; negative regulation of protein amino acid phosphorylation; negative regulation of protein phosphatase type 2B activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; positive regulation of protein ubiquitination; protein peptidyl-prolyl isomerization; regulation of activin receptor signaling pathway; regulation of immune response; regulation of protein localization; release of sequestered calcium ion into cytosol; response to caffeine; SMAD protein complex assembly; T cell proliferation; ventricular cardiac muscle morphogenesis
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Product Notes
The FKBP1A fkbp1a (Catalog #AAA140934) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSHMG VQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK FDSSRDRNKP FKFTLGKQEV IRGWEEGVAQ MSVGQRAKLI ISSDYAYGAT GHPGIIPPHA TLVFDVELLK LE. It is sometimes possible for the material contained within the vial of "FK506 Binding Protein 1A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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