Mouse FK506 binding protein 1A, 12kDa ELISA Kit | FKBP1A elisa kit
Mouse Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP1A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Description
FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.
Protein type: EC 5.2.1.8; Isomerase
Cellular Component: extracellular matrix; sarcoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; cell; cytoplasm; nerve terminal; intracellular; cytosol; Z disc
Molecular Function: protein homodimerization activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; isomerase activity; drug binding; Hsp70 protein binding; protein binding; signal transducer activity; enzyme binding; activin binding; calcium channel inhibitor activity; SMAD binding; transforming growth factor beta receptor binding
Biological Process: heart morphogenesis; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein peptidyl-prolyl isomerization; positive regulation of protein binding; protein folding; cytokine and chemokine mediated signaling pathway; regulation of activin receptor signaling pathway; SMAD protein complex assembly; response to caffeine; negative regulation of protein phosphatase type 2B activity; T cell proliferation; regulation of protein localization; muscle contraction; negative regulation of protein amino acid phosphorylation; positive regulation of protein ubiquitination; negative regulation of release of sequestered calcium ion into cytosol; release of sequestered calcium ion into cytosol; fibril organization and biogenesis; ventricular cardiac muscle morphogenesis
Research Articles on FKBP1A
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Product Notes
The Mouse FKBP1A fkbp1a (Catalog #AAA9336876) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336876 ELISA Kit recognizes Mouse FKBP1A. It is sometimes possible for the material contained within the vial of "FK506 binding protein 1A, 12kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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