FKBP11 recombinant protein

FKBP11 Protein, Human, Recombinant (mFc Tag)

Cat. Num. AAA8121493

• Gene Names: FKBP11; FKBP19
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FKBP11; FKBP11 Protein; Human; Recombinant (mFc Tag); Human FKBP11/FKBP-11 Protein (Fc Tag); FKBP19 Protein; FK506 binding protein 11; 19kDa; FKBP11 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly155

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 28
• Tag: C-mouse IgG1-Fc
• Protein Construction: A DNA sequence encoding the human FKBP11 (NP_057678.1)(Met1-Gly155) was expressed with the Fc region of mouse IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FKBP11 recombinant protein

Background: FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC.

NCBI and Uniprot Product Information

• NCBI GI #: 7706131
• NCBI GeneID: 51303
• NCBI Accession #: NP_057678.1
• NCBI GenBank Nucleotide #: NM_016594.2
• UniProt Accession #: Q9NYL4; B4DWB7
• Molecular Weight: 15,769 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1
• NCBI Official Synonym Full Names: FK506 binding protein 11, 19 kDa
• NCBI Official Symbol: FKBP11
• NCBI Official Synonym Symbols: FKBP19
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP11; FKBP-11; FKBP-19; rotamase; 19 kDa FKBP; PPIase FKBP11; FK506-binding protein 11; 19 kDa FK506-binding protein
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP11
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: FKBP11
• UniProt Synonym Gene Names: FKBP19; PPIase FKBP11; 19 kDa FKBP; FKBP-19; FKBP-11
• UniProt Entry Name: FKB11_HUMAN

NCBI Description

FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

Uniprot Description

FKBP11: PPIases accelerate the folding of proteins during protein synthesis. Belongs to the FKBP-type PPIase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: peptidyl-prolyl cis-trans isomerase activity; FK506 binding

Biological Process: protein peptidyl-prolyl isomerization